Process and intermediates for manufacture of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid
US4600534A · kind A · utility
11Cited by
1References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 18, 1984 |
| Grant date | Jul 15, 1986 |
| Priority date | — |
| Expiry date | Oct 18, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0222
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention concerns a novel process for the preparation of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid by opening, preferably under acidic conditions, the caprolactam ring in a compound of formula II ##STR1## wherein COR represents carboxy or esterified carboxy, and hydrolyzing the esterified carboxy group if present. The preparation of the starting materials of formula II is described.
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