Pharmaceutical preparation

US4600721A · kind A · utility

Assignee

• Ludwig Heumann & Co. GmbH · DE

Inventors

• Peter Morsdorf · Langenzenn, DE
• Helmut Schickaneder · Eckental, DE
• Heidrun Engler · Cadolzburg, DE
• Istvan Szelenyi · Arnstorf, DE
• Kurt H. Ahrens · Nürnberg, DE
• Kay Brune · Marloffstein, DE

Key dates

• Filing date: Mar 27, 1985
• Grant date: Jul 15, 1986
• Expiry date: Mar 27, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/82
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical preparations having an antiphlogistic action are described. The preparations contain, as active ingredient, a benzazole derivative corresponding to the general tautomeric formulae I ##STR1## wherein X represents a sulphur or oxygen atom and R.sup.1 represents a hydrogen atom and R.sup.2 a hydroxymethyl, formyl, lower carbalkoxy or lower acyl group or R.sup.1 and R.sup.2 together represent the group ##STR2## wherein R.sup.3 and R.sup.4 denote, independently of one another, a hydrogen atom or a C.sub.1 -C.sub.6 -alkyl group, or they contain a physiologically acceptable salt thereof. These pharmaceutical preparations are suitable in particular for the treatment of inflammatory conditions and for inhibiting the lipoxygenase and/or cyclooxygenase route of arachidonic acid metabolism.