Cyclic octapeptides and pharmaceutical preparations thereof, as well as processes for their manufacture, and their use
US4603120A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 20, 1982 |
| Grant date | Jul 29, 1986 |
| Priority date | — |
| Expiry date | Dec 20, 2002 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cyclic octapeptides of the formula ##STR1## in which Aaa represents a radical of a straight-chained .alpha.,.omega.-diaminoalkanoic acid having from 4 to 7 carbon atoms, PA0 trp represents a radical L-Trp or, especially, D-Trp, or a radical derived therefrom, which carries a halogen atom in the indole nucleus, PA0 Ac.sub.A represents an acyl radical Ac of an optionally substituted carboxylic acid which is positioned at the .omega.-amino group, or represents an amidino group or hydrogen, and PA0 Ac.sub.B represents an acyl radical Ac.sup.1 of an amino acid or of an oligopeptide which is positioned at the .epsilon.-amino group, or, preferably, represents hydrogen, as well as physiologically tolerable salts and therapeutically acceptable complexes thereof can be used as antidiabetics and for the treatment of gastro-intestinal bleeding in an analogous manner to somatostatin. They can be obtained by conventional processes of peptide chemistry, especially by the cyclization of corresponding linear peptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.