Bicycle compounds, processes for their preparation and pharmaceutical formulations containing compounds

US4603139A · kind A · utility

Assignee

• Burroughs Wellcome Co. · US

Inventor

• William R. King · Bartlesville, US

Key dates

• Filing date: Jan 11, 1985
• Grant date: Jul 29, 1986
• Expiry date: Jan 11, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula (I'), and compositions containing them: ##STR1## wherein n is 1, 2 or 3, each R.sub.1 independently represents a halogen atom; a hydroxy, carboxyl or C.sub.1-4 alkyl group, a C.sub.2-4 alkenyloxy, phenyl or phenyl-C.sub.1-4 alkoxy group which may be optionally substituted by one or more halogen atoms; an amino, mono- or dialkyl-amino, morpholino or piperazino group; a group of formula --S(O).sub.x R.sub.a where x is 0, 1 or 2 and R.sub.a is a C.sub.1-4 alkyl group; or a C.sub.1-4 alkoxy group which may be optionally substituted by one or more radicals selected from hydroxy, C.sub.1-4 alkoxy, amino, mono- or di-C.sub.1-4 alkylamino, (phenyl-C.sub.1-4 alkyl)amino, N,N-C.sub.1-4 alkyl(phenyl-C.sub.1-4 alkyl)amino and N,N-(C.sub.1-4 alkoxyphenyl-C.sub.1-4 alkyl)C.sub.1-4 alkyl-amino; n is 1, 2 or 3; m is 0 or 1; R.sub.2 represents a C.sub.1-4 alkyl group in the 1- or 3-position of the imidazo ring; R.sub.3 represents a hydrogen or halogen (fluorine, chlorine, bromine or iodine) atom, or a hydroxy, amino or C.sub.1-4 alkyl or alkoxy group; and physiologically acceptable acid addition salts thereof and N-oxides of such compounds and salts. Formula (I') includes the a…