Benzazepine derivatives

US4604389A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Manfred Reiffen · Biberach, DE
• Klaus Noll · Cologne, DE
• Joachim Heider · Warthausen, DE
• Volkhard Austel · Biberach, DE
• Norbert Hauel · Schemmerhofen, DE
• Walter Kobinger · Wien, AT
• Christian Lillie · Wien, AT

Key dates

• Filing date: May 8, 1985
• Grant date: Aug 5, 1986
• Expiry date: May 8, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to benzazepine derivatives of formula I ##STR1## wherein A is --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--; PA1 R.sub.1 is hydrogen, chlorine, bromine, C.sub.1 -C.sub.3 alkyl, amino, C.sub.1 -C.sub.3 alkylamino, C.sub.1 -C.sub.3 dialkylamino, acylamino, hydroxy, C.sub.1 -C.sub.3 alkoxy or phenyl C.sub.1 -C.sub.3 alkoxy; PA1 R.sub.2 is hydrogen, chlorine, bromine, hydroxy, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy or phenyl C.sub.1 -C.sub.3 alkoxy or, together with R.sub.1, can be C.sub.1 -C.sub.3 alkylenedioxy; PA1 R.sub.3 is hydrogen, chlorine, bromine or C.sub.1 -C.sub.3 alkoxy; PA1 R.sub.4 is hydrogen, benzyl, C.sub.1 -C.sub.3 alkyl or C.sub.3 -C.sub.5 alkenyl; PA1 R.sub.5 is hydrogen, halogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy; PA1 R.sub.6 is hydrogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy or, together with R.sub.5, can be a C.sub.1 -C.sub.2 alkylenedioxy; PA1 X is an imino, optionally substituted by a benzyl or C.sub.1 -C.sub.3 alkyl, or is oxygen, sulphur, sulphinyl or sulphonyl; PA1 Y is an imino, optionally substituted by a benzyl or C.sub.1 -C.sub.3 alkyl, or is methylene or carbonyl; PA1 m and n are each independently 2,…