Antibacterial benzo(chalcogeno)[4,3,2-cd]indazoles

US4604390A · kind A · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Edward Faith Elslager · Ann Arbor, US
• Leslie M. Werbel · Ann Arbor, US
• Daniel Fred Ortwine · San Ramon, US
• Donald F. Worth · Ann Arbor, US
• Howard Daniel Hollis Showalter · Ann Arbor, US
• David B. Capps · Ann Arbor, US
• Ellen M. Berman · Ann Arbor, US
• Vlad Edward Gregor · Del Mar, US
• Anthony D. Sercel · Ann Arbor, US

Key dates

• Filing date: May 24, 1985
• Grant date: Aug 5, 1986
• Expiry date: May 24, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C09B11/28
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted 2H-[1]benzopyrano[4,3,2-cd]indazoles, 2H-[1]benzothiopyrano[4,3,2-cd]indazoles, and 2H-[1]benzoselenino[4,3,2-cd]indazoles have demonstrated pharmacological activity against a broad spectrum of Gram-positive and Gram-negative bacteria, yeasts, and fungi, as well as activity against the L1210 and P388 murine leukemia cells lines. Pharmaceutical compositions containing the compounds and methods of employing the compounds in methods of treating bacterial or fungal infections and of inhibiting the growth of neoplasms in mammals are also disclosed.