1-oxadethiacepham compounds
US4604460A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 17, 1983 |
| Grant date | Aug 5, 1986 |
| Priority date | — |
| Expiry date | Oct 17, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D505/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Intermediates for preparaing an antibacterial 1-dethia-1-oxacephalosporins which are represented by the following formula: ##STR1## wherein R is a monovalent group (minus the carbonyl) from an acyl derived from a carboxylic or carbonic acid; PA0 Y.sup.1 is a divalent group of the following formula: ##STR2## wherein COB is carboxy or protected carboxy; PA1 X is hydrogen or a nucleophilic group; and PA1 Z is a leaving group are prepared from a compound of the following formula: ##STR3## wherein R and Y.sup.1 are as defined above by the action of an acid. The new compounds of this invention shown by the following formula: ##STR4## wherein A is amino or substituted amino; PA0 E is hydrogen or methoxy; and PA0 Y is a divalent group of the following formula: ##STR5## in which COB, X, and Z are as defined above are convertible into other compounds of the same formula by applying conventional methods in .beta.-lactam chemistry.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.