1,1-diphenylpropanol derivatives, process for their preparation and pharmaceutical compositions containing them
US4605785A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 27, 1983 |
| Grant date | Aug 12, 1986 |
| Priority date | — |
| Expiry date | Dec 27, 2003 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to new 1,1-diphenylpropan-1-ol derivatives of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms, PA0 R.sub.3 is halogen, trihalomethyl, alkyl having from one to 5 carbon atoms or alkoxy having from one to 5 carbon atoms, PA0 R.sub.4 is phenyl optionally substituted by one or more identical or different substituents selected from the group of halogen, trihalomethyl, alkyl, alkoxy, cyano, nitro, amino, alkylamino, dialkylamino, hydroxyl, carboxyl or substituted carboxyl; dialkylaminocarbonyl or alkoxycarbonyl containing from one to 4 carbon atoms in the alkyl and alkoxy moieties, respectively, PA0 n is 1, 2, 3, 4, or 5. According to another aspect of the invention there are provided processes for the preparation of the compounds of formula (I). The new compounds induce the polysubstrate monooxigenase enzyme system of liver and are devoid from other pharmacodinamic effects. Pharmaceutical compositions containing compounds of the formula (I) as active ingredient are also within the scope of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.