Biochemical process for optical resolution of cyclopentenolone derivatives
US4607013A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 7, 1984 |
| Grant date | Aug 19, 1986 |
| Priority date | — |
| Expiry date | Sep 7, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P7/26
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A biochemical process for optical resolution of 4-hydroxy-3-methyl-2-2'-propynyl-2-cyclopentenone, which comprises asymmetrically hydrolyzing organic carboxylic acid (saturated or unsaturated carboxylic acids having 1 to 18 carbon atoms) esters of (.+-.)-4-hydroxy-3-methyl-2-2'-propynyl-2-cyclopentenone by the action of an esterase originated from a microorganism or an animal pancreas to give optically active 4-hydroxy-3-methyl-2-2'-propynyl-2-cyclopentenone and esters of its antipode with high optical purity is disclosed. This resolution process is simple in steps as compared with the conventionally known organic chemical methods of optical resolution, and is quite advantageous industrially because it does not require expensive optically active reagents.
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