Antihypertensive 2-phenyl Hantzsch dihydropyridines
US4607041A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 17, 1984 |
| Grant date | Aug 19, 1986 |
| Priority date | — |
| Expiry date | Apr 17, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There are described compounds of formula I, ##STR1## in which R.sub.1 represents benzofurazanyl, pyridyl or phenyl, the pyridyl or phenyl being substituted by one or more of the groups halogen, nitro, --CN, --OR.sub.9, --S(O).sub.p R.sub.9, or alkyl C1 to 6 optionally substituted by halogen, PA1 p is 0, 1 or 2, PA1 R.sub.2 and R.sub.3, which may be the same or different, each represent hydrogen; alkyl C1 to 6 optionally substituted by one or more of the groups halogen, cyano, --XR.sub.4, --NR.sub.5 R.sub.6 or phenyl; cycloalkyl C3 to 8 optionally substituted by alkyl C1 to 6; a 4, 5 or 6 membered oxygen or nitrogen containing heterocyclic ring which is optionally substituted by alkyl C1 to 6 the alkyl in turn optionally being substituted by one or more phenyl groups; PA1 R.sub.5 and R.sub.6, which may be the same or different, each represent alkyl C1 to 6 optionally substituted by phenyl, PA1 Y and Z together form a bond, and additionally, when R.sub.8 is an electron withdrawing group Y may be hydrogen and Z may be hydroxy, PA1 one of R.sub.7 and R.sub.8 represents alkyl C1 to 6 and the other represents phenyl, PA1 or R.sub.7 and R.sub.8 may be the same or different and each repres…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.