Process for the preparation of 3-isomers of 1-cyclohexyl-2-(1,2,4-triazol-1-yl)-1-penten-3-one derivatives

US4607108A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Peter Feyen · Mettmann, DE
• Gebhard Rauleder · Goldkronach, DE
• Wolf Reiser · Wuppertal, DE

Key dates

• Filing date: Jun 22, 1984
• Grant date: Aug 19, 1986
• Expiry date: Jun 22, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The known E-isomers of compounds of the formula ##STR1## in which X and Y independently of each other represent hydrogen or halogen, are obtained according to a new process, in which triazolylketones of the formula ##STR2## in which X and Y have the above mentioned meaning, are reacted with an excess of cyclohexanecarbaldehyde in the presence of a non-polar organic diluent and in the presence of a catalyst mixture of organic acids and secondary amines in a molar ratio of 1:0.5 to 1:1 at temperatures between 40.degree. and 100.degree. C. by continuously removing the water formed and subsequently working up in the manner that is described in the specification.