1-hydroxy-1,1-diphosphonic acids and cytostatic use thereof

US4608368A · kind A · utility

Assignee

• Henkel Kommanditgesellschaft auf Aktien · DE

Inventors

• Helmut Blum · Goldkronach, DE
• Wolfgang Greb · Dinslaken, DE
• Hinrich Moeller · Monheim, DE
• Dietrich Schmaehl · Heidelberg, DE
• Harald Schnegelberger · Leichlingen, DE
• Hannsjoerg Sinn · Wiesloch, DE
• Franz Wingen · Heidelberg, DE

Key dates

• Filing date: Jul 10, 1985
• Grant date: Aug 26, 1986
• Expiry date: Jul 10, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/3873
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

1-hydroxy-1,1-diphosphonic acid compounds corresponding to the following general formula ##STR1## in which R and R.sub.1 represent hydrogen or methyl, PA1 X represents hydrogen, halogen, amino, which may be acyl substituted, lower alkyl, which may be substituted by amino or acyl substituted amino, or lower alkoxy, PA1 Y represents O, S or NH PA1 Z represents lower alkylene, which may be substituted by amino or acyl substituted amino, and PA1 m and n have the value 0 or 1 with the proviso that, where n is 1, m is also 1; PA1 and to pharmacologically compatible salts thereof. The invention also relates to a process for producing these compounds and to their use in pharmacological preparations having cytostatic activity.