Clavulanic acid ethers as antibacterial agents
US4609495A · kind A · utility
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Key dates
| Filing date | Jun 29, 1981 |
| Grant date | Sep 2, 1986 |
| Priority date | — |
| Expiry date | Jun 29, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D503/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The compounds of the formula (II): ##STR1## and salts and esters thereof wherein R is an inert organic group of up to 18 carbon atoms and are able to inhibit the action of various bacterial .beta.-lactamases. Thus when a compound of the formula (II) or its salt or ester is used together with a penicillin or cephalosporin, the effectiveness of that penicillin or cephalosporin can be considerably enhanced. These novel synergysts can be prepared by etherification of an ester of clavulanic acid followed if desired by deesterification. The novel synergysts also possess antibacterial activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.