1-(Alkanoylamino-aryloxy)-2-hydroxy-3-(alkinyl-amino)-propanes and salts thereof

US4609672A · kind A · utility

Assignee

• C. H. Boehringer Sohn · DE

Inventors

• Herbert Koppe · Ingelheim am Rhein, DE
• Werner Kummer · Ingelheim am Rhein, DE
• Helmut Stahle
• Gojko Muacevic · Ingelheim am Rhein, DE
• Werner Traunecker · Münster-Sarmsheim, DE

Key dates

• Filing date: Jun 25, 1984
• Grant date: Sep 2, 1986
• Expiry date: Jun 25, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a compound of the formula ##STR1## wherein R.sub.1 is a linear or branched alkyl of 4 to 20 carbon atoms; PA0 R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or a bivalent radical --CH.dbd.CH--CH.dbd.CH-- or --(CH.sub.2).sub.n --, where n is an integer from 3 to 5, inclusive, and the free bonds of said bivalent radical are attached to adjacent carbon atoms of the phenyl ring; and PA0 R.sub.3 is hydrogen or alkyl of 1 to 3 carbon atoms; PA0 R.sub.4 is alkyl of 1 to 3 carbon atoms; or PA0 R.sub.3 and R.sub.4, together with each other, are --(CH.sub.2).sub.p --, where p is an integer from 4 to 6, inclusive, or a non-toxic, pharmacologically acceptable acid addition salt thereof. The compounds of formula I are useful for treatment and prophylaxis of diseases of the coronaries, for the treatment of hypertension, and for treatment of cardiac arrhythmia, particularly tachycardia.