Tricyclic amines with central dopaminergic activity

US4612316A · kind A · utility

Assignee

• Astra Lakemedel Aktiebolag · SE

Inventors

• Bengt R. Andersson · Göteborg, SE
• Folke L. Arvidsson · Uppsala, SE
• Per A. E. Carlsson · Göteborg, SE
• John S. M. Hjort · Gothenburg, SE
• Anette Johansson · Järlåsa, SE
• Per L. Lindberg · Mölndal, SE
• John L. G. Nilsson · Tullinge, SE
• Domingo Sanchez · Floda, SE
• Kjell A. I. Svensson · Alingsås, SE
• Hakan V. Wikstrom · Mölndal, SE

Key dates

• Filing date: Apr 19, 1984
• Grant date: Sep 16, 1986
• Expiry date: Apr 19, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein C.sup.1 and N.sup.4 are in trans configuration to each other, wherein R and Y are defined herein below, as bases and pharmaceutically acceptable acid addition salts thereof, processes for their preparation and pharmaceutical preparations and methods of treatment employing such compounds. The compounds are useful for treatment of disorders in the central nervous system.