Gastrin releasing peptide-like peptides

US4613586A · kind A · utility

Assignee

• Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Jack D. Barchas · Stanford, US
• Eckard Weber · San Diego, US
• Christopher J. Evans · Higganum, US
• Jaw-Kang Chang · Redwood City, US
• Robin G. Lorenz · Okeene, US
• Kevin Aaron Roth · Mountain View, US

Key dates

• Filing date: Apr 19, 1984
• Grant date: Sep 23, 1986
• Expiry date: Apr 19, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel peptides having gastrin releasing peptide-like activity having the structures Ala-Pro-Val-Ser-Val-Gly-Gly-Gly-Thr-Val-Leu-Ala-Lys-Met-Tyr-Pro-NH.sub.2 and Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH.sub.2, have been isolated from rat and guinea pig brain extracts and synthesized by a solid phase peptide synthesis methods. The GRP-like peptides are useful as pharmaceuticals to lower body temperature, increase respiratory activity, reduce food intake, stimulate pancreatic hormone release, stimulate pituitary hormone release and suppress thyroid hormone release in mammals.