Aminocyclopentanes and their preparation and pharmaceutical formulation
US4613597A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 5, 1984 |
| Grant date | Sep 23, 1986 |
| Priority date | — |
| Expiry date | Sep 5, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/1896
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds are described of the formulae (1a) and 1b) ##STR1## in which: R.sup.1 is -H, C.sub.1-6 alkyl or C.sub.7-10 aralkyl, PA1 W is C.sub.1-7 alkylene PA1 X is cis or trans --CH.dbd.CH--, PA1 Y is a saturated heterocyclic amino group having 5-8 ring members, PA1 R.sup.2 is (i) substituted or unsubstituted phenylalkyl, thienylalkyl or naphthylalkyl or (ii) cinnamyl, and Z is --CH.sub.2 OH, --CHO or --CONHR.sup.4 where R.sup.4 is --H or methyl, PA1 and their salts and solvates. These compounds inhibit blood platelet aggregation, bronchoconstriction and vasoconstriction, and may be formulated for use as antithrombotic and antiasthmatic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.