Preparation of amino acids from unsaturated hydantoins
US4613691A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 8, 1985 |
| Grant date | Sep 23, 1986 |
| Priority date | — |
| Expiry date | Jul 8, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P41/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Amino acids can be easily prepared by reducing unsaturated hydantoins to the corresponding saturated hydantoins by hydrogenating the unsaturated hydantoin using either Raney Nickel catalyst in the presence of more than a stoichiometric amount of caustic or by using zinc and hydrochloric acid followed by hydrolyzing the resultant composition with at least 3 molar equivalents of an alkali metal hydroxide to produce a racemate of an alpha amino acid. The amino acid in suitable derivative form can then be resolved particularly using a two-phase solvent system. The residual isomer of the amino acid remaining after the resolution process can then be racemized using either pyridoxal-5-phosphate or an aliphatic acid in combination with an aldehyde or a ketone. By these procedures, it is possible to obtain high yields of amino acids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.