Process for the manufacture of optically active azetidinones
US4614614A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 22, 1984 |
| Grant date | Sep 30, 1986 |
| Priority date | — |
| Expiry date | Mar 22, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to an improved process for the manufacture of (3S)-3,4-trans-disubstituted azetidinones of the formula ##STR1## in which R.sub.1 represents hydrogen or lower alkyl, PA0 R.sub.2 represents hydrogen or a hydroxy-protecting group, PA0 Y represents the group --S(.dbd.O)--R.sub.3 or --S(.dbd.O).sub.2 --R.sub.3 wherein R.sub.3 represents an organic radical bonded to the sulphur atom by a carbon atom that is not bonded to hydrogen, or the group --C(.dbd.O)--O--R.sub.3 ' wherein R.sub.3 ' represents an organic radical bonded to the oxygen atom of the carboxy group by a carbon atom that is not bonded to hydrogen, or a carboxy-protecting group, and PA0 R.sub.4 represents hydrogen or an amino-protecting group R.sub.4 '. The process according to the invention is carried out under particularly favorable reaction conditions and yields compounds (I) in particularly high yields.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.