Hepatitis A--subunit antigen
US4614793A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 2, 1984 |
| Grant date | Sep 30, 1986 |
| Priority date | — |
| Expiry date | Mar 2, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/223
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A surface structural protein of Hepatitis A Virus (HAV) has been isolated and characterized from virus grown in tissue culture. This 33,000 dalton viral protein (VP-1) reacts with immune HAV sera and monoclonal antibodies that neutralize HAV infectivity. The VP-1 is usable for the preparation of a polypeptide subunit vaccine for HAV. Hybridoma cells were made which produced monoclonal antibodies to HAV or VP-1. These monoclonal antibodies were found to neutralize the infectivity of HAV and to compete with polyclonal antibody derived from human HAV immune sera. The monoclonal antibodies are useful for the neutralization of infectious HAV, the detection of antibodies to neutralizing sites on HAV, and the diagnoses of HAV disease in humans and other susceptible hosts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.