Novel apovincaminic acid derivatives
US4614824A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 11, 1985 |
| Grant date | Sep 30, 1986 |
| Priority date | — |
| Expiry date | Jul 11, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to new racemic and optically active apovincaminic acid derivatives of the general formula (I) ##STR1## wherein A is hydroxyl, halogen or a group --O--(CH.sub.2).sub.n --OR.sup.1 or --OMe, in which PA1 R.sup.1 is alkyl having from one to 6 carbon atoms, PA1 n is an integer between 2 and 6, PA1 Me is an alkali metal, PA0 R.sup.2 stands for an alkyl group having from one to 6 carbon atoms, which may be identical with or different from R.sup.1, and the hydrogen in the 3-position and the R.sup.2 group have an .alpha.,.alpha.- and/or .beta.,.beta.- or .alpha.,.beta.- and/or .beta.,.alpha.-configuration, and pharmaceutically acceptable acid addition salts thereof, which are pharmaceutically active, e.g. show antihypoxial activity or are potent peripheral vasodilators. Their preparation and pharmaceutical composition containing them are also within the scope of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.