Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes
US4615699A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 3, 1985 |
| Grant date | Oct 7, 1986 |
| Priority date | — |
| Expiry date | May 3, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A high flux transdermal nitroglycerin therapeutic system is disclosed which is capable of delivering nitroglycerin through intact human skin at rates of 40 .mu.g/cm.sup.2 hr and preferably in the range of 50-150 .mu.g/cm.sup.2 hr. Ethanol delivered at a rate of from 250-500 .mu.g/cm.sup.2 hr is employed as a permeation enhancer for the nitroglycerin and a rate controlling membrane formed from ethylene vinyl acetate having a vinyl acetate content greater than 11% and preferably between 12-18% provides the appropriate rate control for both the drug and the permeation enhancer. This system is suitable for use in treatment of angina pectoris and congestive heart failure.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.