Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides
US4615876A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 25, 1983 |
| Grant date | Oct 7, 1986 |
| Priority date | — |
| Expiry date | Apr 25, 2003 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Stable neutral-lipophilic complexes of technetium-99m (Tc-99m) useful as diagnostic radionuclidic imaging agents are formed by complexing technetium-99m pertechnetate with alkylene amine oximes (viz. propylene amine oxime) in aqueous solutions under reducing conditions. The complexes have a zero charge, contain an O--H--O ring closure bond, and are sufficiently stable for parental administration in imaging by scintillation scanning. Substituents can be attached to the C.sub.2 to C.sub.4 alkylene carbon backbone of the tetradentate amine oxime ligands to structurally modify them and produce a variety of Tc-99m-radiopharmaceuticals with specific body imaging applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.