Novel indole derivatives and pharmaceutical compositions containing same

US4616011A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Manfred Reiffen · Biberach, DE
• Joachim Heider · Warthausen, DE
• Volkhard Austel · Biberach, DE
• Norbert Hauel · Schemmerhofen, DE
• Walter Kobinger · Wien, AT
• Christian Lillie · Wien, AT

Key dates

• Filing date: Nov 26, 1984
• Grant date: Oct 7, 1986
• Expiry date: Nov 26, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to novel indole derivatives of the formula ##STR1## wherein A represents a --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, ##STR2## group and B represents a methylene, carbonyl, or thiocarbonyl group or A represents a --CO--CO-- or ##STR3## group and B represents a methylene group, E represents an alkylene group or a 2-hydroxy-n-propylene, 2-hydroxy-n-butylene, or 3-hydroxy-n-butylene group, PA0 G represents an alkylene group, PA0 R.sub.1 represents a hydrogen, chlorine, or bromine atom or a trifluoromethyl, nitro, amino, alkylamino, dialkylamino, alkyl, hydroxyl, alkoxy, or phenylalkoxy group, PA0 R.sub.2 represents a hydrogen, chlorine, or bromine atom or a hydroxyl, alkoxy, phenylalkoxy, or alkyl group or PA0 R.sub.1 and R.sub.2 together represent an alkylenedioxy group, PA0 R.sub.3 represents a hydrogen, chlorine, or bromine atom or an alkyl group, PA0 R.sub.4 represents a hydrogen atom or an alkyl or phenylalkyl group, PA0 R.sub.5 represents a hydrogen, fluorine, chlorine, or bromine atom or an alkyl, hydroxyl, alkoxy, or phenylalkoxy group, PA0 R.sub.6 represents a hydrogen atom or an alkoxy group, and PA0 R.sub.7 represents a hydrogen atom or an alkenyl, alky…