Medicaments, vicinal dihydroxyalkylxanthines contained therein, processes for the preparation of these xanthine compounds and intermediate products suitable for these

US4616020A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Harald Furrer · Frankfurt am Main, DE
• Hiristo Anagnostopulos · Wiesbaden, DE
• Ulrich Gebert · Königstein, DE
• Heinz-Joachim Hinze · Wiesbaden, DE

Key dates

• Filing date: Sep 17, 1982
• Grant date: Oct 7, 1986
• Expiry date: Sep 17, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein one of the radicals R.sup.1, R.sup.2 or R.sup.3 denotes a straight-chain alkyl group having 4 to 8 C atoms and two vicinal hydroxyl groups in the .omega.,.omega.-1 or .omega.-1,.omega.-2 positions and the two other radicals represent straight-chain or branched alkyl groups having up to 12 C atoms in the position of R.sup.1 and R.sup.3 and up to 4 C atoms in the position of R.sup.2, the total of C atoms in these two alkyl substituents being a maximum of 14, are prepared by oxidation of the corresponding alkenylxanthines and by alkylation with compounds which introduce the dihydroxyalkyl radical or a precursor thereof. The dihydroxyalkyldialkylxanthines are suitable for the treatment of obstructive respiratory tract diseases.