Synergistine derivatives and their preparation
US4617377A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 12, 1984 |
| Grant date | Oct 14, 1986 |
| Priority date | — |
| Expiry date | Jul 12, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/27
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides new synergistine derivatives of the formula: ##STR1## in which Y=H or N(CH.sub.3).sub.2 and R represents: (a) H or OH, PA0 (b) a radical of the formula NR.sub.1 R.sub.2, in which R.sub.1 and R.sub.2 =H, phenyl or pyridyl (optionally substituted by dialkylamino (1 to 4 C), alkyl (1 to 10 C) [optionally substituted by OH, SH, COOH, anilino, or alkylamino or dialkylamino of which at least one of the alkyl parts is substituted by OH, SH, COOH or anilino 9 , alkenyl (3 or 4 C) or alkynyl (3 or 4 C), or alternatively R.sub.1 and R.sub.2 together form a heterocycle optionally containing another heteroatom such as O, S or N (optionally substituted by alkyl), or PA0 (c) a halogen atom, a trimethylsilyloxy or dialkylphosphoryloxy radical or a radical --OSO.sub.2 R.sub.3 or --OCOR.sub.4, R.sub.3 being alkyl, trifluoromethyl, trichloromethyl or optionally substituted phenyl and R.sub.4 being defined in the same way as R.sub.3 or being an acylalkyl, alkoxycarbonylalkyl or alkoxy radical, and also their salts and their preparation. These products are useful as intermediates in the synthesis of anti-bacterial synergistine derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.