Acid-cleavable compound
US4618492A · kind A · utility
43Cited by
1References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 13, 1985 |
| Grant date | Oct 21, 1986 |
| Priority date | — |
| Expiry date | May 13, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Amino-sulfhydryl cross-linking reagents that are cleavable under mildly acidic conditions are disclosed. Also disclosed are methods of making the cross-linkers, as well as methods of using the cross-linkers, e.g., to deliver a biologically active substance across the membranes of selected cells in a heterogeneous cell population; once inside the cell the active substance is released, intact, by the transient, mild acidity of certain cell structure. Finally, a method of characterizing complex multi-chain protein structures is disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.