Process for the preparation of (1S, 4R)-4-hydroxy-2-cyclopentenyl esters

US4618690A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Manfred Schneider · Lichtenfels, DE
• Kurt Laumen · Wuppertal, DE

Key dates

• Filing date: May 15, 1985
• Grant date: Oct 21, 1986
• Expiry date: May 15, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1804
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Optically pure (1S, 4R)-4-hydroxy-2-cyclopentyl ester of the formula ##STR1## in which Ac is an aliphatic acyl radical having 1 to 18 carbon atoms, is produced by contacting a meso such as porcine liver esterase. The products are useful in synthesizing cyclopentanoid products such as brefeldin A, sesquiterpenes and prostaglandins.