Spontaneous preparation of small unilamellar liposomes
US4619794A · kind A · utility
200Cited by
4References
24Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jan 29, 1985 |
| Grant date | Oct 28, 1986 |
| Priority date | — |
| Expiry date | Jan 29, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2984
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a novel advantageous process for the preparation of unilamellar liposomes in aqueous phase by converting a suitable lipid component, e.g. phosphatidic acid, into the ionic form by subjecting the lipid dispersion to a change in pH value and subsequently neutralizing it. Formation of the unilamellar liposomes is spontaneous, i.e. it takes place without additional external supply of energy. The liposomes obtainable by the process of this invention can be used therapeutically as carriers for drugs of the most widely different kind.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.