Phenylpiperazine derivatives of hetarylphenols and hetarylanilines, their preparation, and therapeutic agents containing these compounds

US4619929A · kind A · utility

Assignee

• BASF SE

Inventors

• Peter C. Thieme · Monsheim, DE
• Gerd Steiner · Tauberbischofsheim, DE
• Wolfgang Rohr · Mannheim, DE
• Dieter Lenke · Ludwigshafen, DE
• Josef Gries · Monsheim, DE
• Harald Weifenbach · Ludwigshafen, DE
• Hans-Juergen Teschendorf · Dudenhofen, DE
• Hans P. Hofmann · Schifferstadt, DE
• Horst Kreiskott · Monsheim, DE

Key dates

• Filing date: Mar 19, 1984
• Grant date: Oct 28, 1986
• Expiry date: Mar 19, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/096
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula ##STR1## where R.sup.1 is hydrogen or alkyl of 1 to 4 carbon atoms, R.sup.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R.sup.2, X is oxygen or an NH group, and the heterocyclic structure Het. is 1,3,4-oxadiazolyl, triazolyl, imidazolyl or pyrazolyl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly sedative, neuroleptic and hypotensive properties.