2H-azeto[2,1-a]-isoquinoline derivatives and pharmaceutical compositions containing them
US4622327A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 25, 1984 |
| Grant date | Nov 11, 1986 |
| Priority date | — |
| Expiry date | Oct 25, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to new 2H-azeto[2,1-a]isoquinoline derivatives of formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms, PA1 R.sup.3 is hydroxyl, halogen or an ##STR2## group, wherein PA2 X is oxygen or sulfur, PA2 R.sup.4 is optionally substituted phenyl, and acid addition, metal and quaternary salts thereof. According to the invention the new compounds are prepared by cyclization of the corresponding compounds of formula (II), ##STR3## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, and Hal is halogen. Compounds of formula (I) are pharmaceutically active, in particular are potent analgesic and antipyretic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.