Isobutylene polymer active compound release systems

US4623346A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Miklos von Bittera · Leverkusen, DE
• Rolf Dhein · Krefeld, DE
• Rolf-Volker Meyer · Krefeld, DE
• Roland Rupp · Bensberg, DE

Key dates

• Filing date: Nov 27, 1984
• Grant date: Nov 18, 1986
• Expiry date: Nov 27, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/7076
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In a therapeutic system such as a plaster for administration of an active compound through the skin and comprising a covering layer which is essentially impermeable to the active compound an active compound reservoir layer and a protective layer which can be pulled off and which is essentially impermeable to the active compound, the improvement wherein the reservoir layer contains about 1-30% of active compound in an elastomer mixture comprising at least one of polyisobutylene, polybutadiene oil and paraffin oil, and a tackifying resin. Thereby the active compound can be released in regulated relatively large quantity over a prolonged period of time.