Method of producing a bone substitute material

US4623553A · kind A · utility

Assignee

• Oscobal AG · CH

Inventors

• Peter Ries · Reinach, CH
• Frank Baumgart · Grenchen, CH
• Heinz Mittelmeier · Homburg, DE

Key dates

• Filing date: Jun 4, 1985
• Grant date: Nov 18, 1986
• Expiry date: Jun 4, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/02
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

For producing the bone substitute material from collagen and hydroxyapatite, an aqueous solution of cleaned collagen is mixed with a cross-linking agent causing only a partial cross-linking, and the mixture is lyophilized. The quantity of the cross-linking agent is chosen such that the collagen retains its resorbability and its absorptivity vis-a-vis bodily fluids, the material further showing no undesirable side effects. Preferably less than 1% by weight of formaldehyde, one of the preferred cross-linking agents, is added, with reference to the dry weight of collagen, and sintered apatite grains with a diameter of 50-300 .mu.m are used. Such a bone substitute material is stronger and less tearable as previously known materials and insures a good promotion of the growth of own bone tissue and the substitution by it.