PAF-antagonistic diazepines, methods of use

US4623646A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Jorge Casals-Stenzel · Munich, DE
• Karl-Heinz Weber · Gau-Algesheim, DE
• Gerhard Walther · Bingen, DE
• Albrecht Harreus · Ingelheim am Rhein, DE
• Gojko Muacevic · Ingelheim am Rhein, DE

Key dates

• Filing date: Oct 1, 1985
• Grant date: Nov 18, 1986
• Expiry date: Oct 1, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention discloses a method of treating an individual having a disorder responsive to PAF-antagonist activity by treating the individual with a compound of formula I. ##STR1## wherein A is an anellated and optionally substituted benzene or 5- or 6- membered heterocyclic ring; R.sub.5 and Z are each independently hydrogen or an optionally substituted C.sub.1 -C.sub.8 alkyl, alkenyl or alkynyl; R.sub.6 is an optionally substituted phenyl, or is thienyl or .alpha.-pyridyl; Y is ##STR2## and nontoxic, pharmaceutically acceptable acid addition salts thereof.