Substituted .beta.-carbolines, and use thereof as medicinal agents

US4623649A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Andreas Huth · Berlin, DE
• Ralph Schmiechen · Berlin, DE
• Dieter Rahtz · Berlin, DE
• Dieter Seidelmann · Berlin, DE
• Claus T. Braestrup · Copenhagen, DK

Key dates

• Filing date: Sep 26, 1984
• Grant date: Nov 18, 1986
• Expiry date: Sep 26, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel substituted .beta.-carboline derivatives of Formula I ##STR1## wherein R.sup.3 is an oxadiazolyl residue of the formula ##STR2## wherein R.sup.5 stands for lower alkyl of up to 3 carbon atoms or an ester ##STR3## with R.sup.6 being hydrogen or lower alkyl of up to 3 carbon atoms, R.sup.4 is hydrogen, lower alkyl of up to 3 carbon atoms, or CH.sub.2 OR.sup.9 wherein R.sup.9 is lower alkyl of up to 3 carbon atoms, PA0 R.sup.A is phenyl or a hydrocarbon residue containing 2-10 carbon atoms which can be cyclic or acyclic, saturated or unsaturated, branched or unbranched, and which can optionally be substituted by oxo, formyl OH, O-alkyl of up to 3 carbon atoms or phenyl, and wherein, in a cyclic hydrocarbon residue, a CH.sub.2 -group can be replaced by oxygen, exhibit an effect on the central nervous system and thus are suitable as psychopharmaceuticals.