Process for the preparation and purification of peptides
US4623716A · kind A · utility
19Cited by
3References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 1, 1984 |
| Grant date | Nov 18, 1986 |
| Priority date | — |
| Expiry date | Nov 1, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Peptides, such as calcitonin, having two cysteine residues connected by a disulfide bond are prepared by a process which includes the step of cyclizing the cysteines at a pH of 8.5 to 9.0, and a concentration of 0.4 to 1.8 mg of peptide per ml of solution. These novel conditions produce rapid cyclization with an unforeseen improvement in yield.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.