Substituted derivatives of 2-azabicyclo-[3.3.0]octanes

US4624962A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Rainer Henning · Tokyo, JP
• Hansjorg Urbach · Kronberg, DE
• Rolf Geiger · Frankfurt am Main, DE
• Volker Teetz · Hofheim, DE
• Bernward Scholkens · Kelkheim, DE

Key dates

• Filing date: Feb 1, 1985
• Grant date: Nov 25, 1986
• Expiry date: Feb 1, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula I ##STR1## in which n denotes 0-3, PA0 R.sup.1 and R.sup.1' are the same or different and denote hydrogen, alkyl or alkenyl, phenyl or benzyl, each substituted as desired; PA0 R.sup.2 denotes hydrogen, alkyl or alkenyl; PA0 R.sup.3 denotes hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl or aminoalkyl, alkanoylaminoalkyl, guanidinoalkyl, imidazolylalkyl, indolylalkyl, mercaptoalkyl or alkylthioalkyl, phenylalkyl, hydroxphenylalkyl, phenoxyalkyl or phenylthioalkyl, or R.sup.2 and R.sup.3, together with the C and N atoms carrying them, denote a saturated or unsaturated 4- to 8-membered monocyclic or 8- to 10-membered bicyclic isocycle or heterocycle, optionally monosubstituted or disubstituted by hydroxyl, alkoxy having 1 to 3 C atoms or alkyl, PA0 R.sup.4 denotes hydrogen, alkyl, alkenyl, alkadienyl, alkinyl, alkeninyl or alkadiinyl, cycloalkyl, phenyl, benzyl, phenethyl or phenylpropyl, each of which can be optionally monosubstituted or disubstituted; PA0 R.sup.5 denotes hydrogen or alkyl, hydroxyl or alkoxy and PA0 R.sup.6 denotes hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, optionally monosubstituted or disubstituted phenyl or naphthyl, their sa…