Oxirane intermediates of 1-hydroxyethyl azole compounds

US4626595A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Graham Holmwood · Wuppertal, DE
• Karl H. Buchel · Burscheid, DE
• Klaus Lurssen · Wittlich, DE
• Paul-Ernst Frohberger · Leverkusen, DE
• Wilhelm Brandes · Leichlingen, DE

Key dates

• Filing date: Jan 28, 1985
• Grant date: Dec 2, 1986
• Expiry date: Jan 28, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D303/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

According to the present invention 1-hydroxyethyl azole compounds are provided for in a process characterized by reacting an oxirane of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical, PA0 Y represents a grouping --OCH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--, PA0 Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical and PA0 m is 0, 1, 2 or 3, PA0 with an azole of the general formula ##STR2## in which X represents a nitrogen atom or a CH group.