Vitro diagnostic methods using monoclonal antibodies against connective tissue proteins
US4628027A · kind A · utility
Assignees
Inventor
Key dates
| Filing date | Apr 18, 1984 |
| Grant date | Dec 9, 1986 |
| Priority date | — |
| Expiry date | Apr 18, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/815
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Collagen profiles of human body tissues and fluids, i.e., the types of distinct connective tissue proteins present, their distribution in human body tissues and fluids, and the concentration ratios among distinct types, are subject to change during certain pathological conditions and during therapeutic regimens for the treatment of such conditions. These changes in collagen profiles can be detected by immunohistological, immunocytological and immunoserological techniques. In vitro diagnostic methods employing monoclonal antibodies specific for connective tissue proteins are provided which can be used for monitoring the results of therapeutic measures taken against inflammatory diseases, fibrotic diseases and cancer and for detecting or following the pathogenesis of such diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.