1,4-naphthoquinone derivatives having anti-inflammatory action

US4628062A · kind A · utility

Assignee

• Troponwerke GmbH & Co. KG · DE

Inventors

• Wolfgang Opitz · Overath, DE
• Bernhard Pelster · Sankt Augustin, DE
• Romanis Fruchtmann · Cologne, DE
• Udo Krupka · Marburg, DE
• Walter Gauss · Cologne, DE
• Hartmut Kiehne · Odenthal, DE
• Hermann Oediger · Cologne, DE

Key dates

• Filing date: Dec 17, 1984
• Grant date: Dec 9, 1986
• Expiry date: Dec 17, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C50/38
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New compounds of the formula ##STR1## in which R.sub.1 is an allylamino, acetylamino or propionylamino radical, PA1 R.sub.2 is hydrogen or a 2-methoxyethoxy or ethoxy radical, PA1 R.sub.3 is hydrogen or a sulphamoyl radical, and PA1 R.sub.4 is hydrogen, and of the formula ##STR2## in which R.sub.1 is a halogen atom or a free or substituted hydroxyl, sulphhydryl or amino group, PA1 R.sub.2 is a hydrogen atom, an alkyl radical, a halogen atom, or a free or substituted hydroxyl, sulphhydryl or amino group, PA1 R.sub.3 and R.sub.4 each independently is hydrogen, alkyl, hydroxyl, alkoxy, sulphonamido or halogen, with the proviso that R.sub.2, R.sub.3 and R.sub.4 are hydrogen when R.sub.1 is hydroxyl, exhibit anti-inflammatory activity.