Intermediate 8-carboxaldehyde-(-chromone and -thiochromone) derivatives

US4628107A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Siegfried Goldmann · Wuppertal, DE
• Gerhard Franckowiak · Wuppertal, DE
• Matthias Schramm · Cologne, DE
• Gunter Thomas · Arese, IT
• Rainer Gross · Wuppertal, DE

Key dates

• Filing date: Jun 28, 1985
• Grant date: Dec 9, 1986
• Expiry date: Jun 28, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel chromone-8-aldehydes and thiochromone-8-aldehydes, useful in making pharmaceutically active dihydropyridines, of the formula ##STR1## in which R.sub.1 represents hydrogen, a C.sub.1 -C.sub.10 aliphatic hydrocarbon radical, a C.sub.1 -C.sub.10 alkyl carboxylate, or an aromatic or heteroaromatic ring which optionally has 1-5 identical or different halogen, C.sub.1 -C.sub.10 -alkyl, C.sub.1 -C.sub.10 -alkoxy, C.sub.1 -C.sub.10 -alkylthio, C.sub.1 -C.sub.10 -alkylsulphinyl, cyano, hydroxyl, nitro, C.sub.1 -C.sub.5 -monofluoroalkyl or polyfluoroalkyl, C.sub.1 -C.sub.5 monofluoroalkoxy or polyfluoroalkoxy, C.sub.1 -C.sub.6 monofluoroalkylthio or polyfluoroalkylthio, amino, C.sub.1 -C.sub.5 -monoalkylamino or C.sub.1 -C.sub.5 dialkylamino substituents, PA0 R.sub.2 represents hydrogen or 1 to 3 halogen atoms, A represents a single bond, a C.sub.1 -C.sub.20 alkylene chain or a C.sub.2 -C.sub.20 alkylene chain which can optionally be interrupted by oxygen or sulphur, and PA0 X represents oxygen or sulphur, are made from corresponding compounds which in 8-position carry an ester or olefinic radical.