Therapeutic agents

US4629727A · kind A · utility

Assignee

• THE BOOTS COMPANY PLC · GB

Inventors

• Antonin Kozlik · Bristol, GB
• Wilfred H. Wells

Key dates

• Filing date: Sep 28, 1983
• Grant date: Dec 16, 1986
• Expiry date: Sep 28, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## in which n=0 or 1; in which, when n=0, R.sub.1 is H, an alkyl, a cycloalkyl, a cycloalkylmethyl, an alkenyl or, an alkynyl group a heterocyclic ring or an optionally substituted phenyl ring or when n=1, R.sub.1 is H or an alkyl group; PA0 in which R.sub.2 and R.sub.3 are H or an alkyl group; PA0 in which A is a group of formula III EQU --(CH.sub.2).sub.x --W--(CH.sub.2).sub.y -- III PA0 in which W is an oxygen atom or a group of formula --S(O).sub.m --, a group of formula --CR.sub.12 R.sub.13 --, a cycloalkylidene group or a cycloalkylene group; x is 0 or an integer from 1 to 5; y is 0 or an integer from 1 to 5. PA0 in which R.sub.4 is a carbocyclic ring, a heterocyclic ring, a cyano group, a carbamoyl group, an alkoxycarbonyl group, an amido group, an acyloxy group, a hydroxy group, a thiol group, or a group of formula --OR.sub.20, --SR.sub.20, --SOR.sub.20 or SO.sub.2 R.sub.20. PA0 in which R.sub.5, R.sub.6 and R.sub.7 are H, halo, trifluoromethyl, hydroxy, an alkyl group, an alkoxy or alkylthio group, phenyl or R.sub.5 and R.sub.6, together with the carbon atoms to which they are attached, form an optionally substituted second benzene ring; PA0 in…