Antihypoxemic 5-(4-substituted piperazinyl)alkyl-8-substituted quinolines
US4629728A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 26, 1984 |
| Grant date | Dec 16, 1986 |
| Priority date | — |
| Expiry date | Dec 26, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65586
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Quinoline compounds of the formula: ##STR1## in which: ##STR2## represents a group of the formula: ##STR3## in which: R' is hydrogen or methyl, PA1 R and R" which are the same or different, each represents: hydrogen, (C.sub.1 -C.sub.5) alkyl, (C.sub.1 -C.sub.5) acyl haloacyl or aminoacyl, (C.sub.1 -C.sub.3) alkylsulfonyl, or diethylphosphonyl; PA1 n is an integer form 1 to 4 inclusive; PA1 T is phenyl, halophenyl, trifluoromethylphenyl [(C.sub.1 -C.sub.5) alkyl] phenyl, [(C.sub.1 -C.sub.5) alkoxy] phenyl, or a five or six-membered heterocyclic radical containing one or two atoms selected from nitrogen and sulfur atoms optionally substituted by one or more (C.sub.1 -C.sub.5) alkyl or (C.sub.1 -C.sub.5) alkoxy. These compounds and physiologically tolerable acid addition salts thereof may be used a medicines especially in the treatment of disorders connected with hypoxemia and energetic metabolic insufficiency especially during cerebral aging.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.