Patent · US Expired

C-20- and C-23 modified macrolide derivatives

US4629786A · kind A · utility

10Cited by

14References

23Claims

0Family size

Assignee

ELI LILLY AND COMPANY · US

Inventors

Manuel Debono · Indianapolis, US
Herbert A. Kirst · Indianapolis, US

Key dates

Filing date	May 25, 1984
Grant date	Dec 16, 1986
Priority date	—
Expiry date	May 25, 2004

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H17/08
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

C-20-Modified derivatives of macrolide antibiotics which include demycinosyltylosin (DMT), 20-dihydro-23-demycinosyltylosin (dihydro-DMT), 23-de(mycinosyloxy)tylosin (DMOT), 20-dihydro-23-de(mycinosyloxy)tylosin (dihydro-DMOT), 5-O-mycaminosyltylonolide (OMT), 20-dihydro-5-O-mycaminosyltylonolide (dihydro-OMT), 23-deoxy-5-O-mycaminosyltylonolide (DOMT), and 20-dihydro-23-deoxy-5-O-mycaminosyltylonolide (dihydro-DOMT) inhibit pathogenic bacteria, especially gram-positive bacteria, and Mycoplasma species; and pharmaceutical compositions thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.