Ergoline carboxamides

US4632990A · kind A · utility

Assignee

• Farmitalia Carlo Erba S.p.A. · IT

Inventors

• Luigi Bernardi · Milano, IT
• Enzo Brambilla · Mariano Comense, IT
• Laura Chiodini · Milano, IT
• Enrico di Salle · Milano, IT
• Daniela Ruggieri · Milano, IT
• Osvaldo Sapini · Gallarate, IT
• Aldemio Temperilli · Milano, IT

Key dates

• Filing date: Apr 13, 1983
• Grant date: Dec 30, 1986
• Expiry date: Apr 13, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D457/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There are provided ergoline derivatives of the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group, R.sub.2 represents a hydrogen or halogen atom or a methyl group, R.sub.3 represents a hydrogen atom or a methoxy group, R.sub.4 represents a hydrocarbon group having from 1 to 4 carbon atoms; each of X and W independently represents a hydrogen atom, a methyl group, a chlorine atom or a methoxy group, and n is 0, 1 or 2. A method for their preparation is also provided. The compounds have strong antiprolactin activity.