Process for the preparation of oxiranes

US4632999A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Rudolf Zerbes · Wuppertal, DE
• Siegfried W. Linke · Wuppertal, DE
• Karl H. Mohrmann · Bensberg, DE
• Wolf Reiser · Wuppertal, DE

Key dates

• Filing date: Oct 22, 1985
• Grant date: Dec 30, 1986
• Expiry date: Oct 22, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D303/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of an oxirane of the formula ##STR1## in which Y represents chlorine or phenyl, X represents oxygen or Ch.sub.2 and Z represents hydrogen or halogen, which comprises containing dimethyl sulphoxide with dimethyl sulphate whereby to form trimethyloxosulphonium methyl sulphate of the formula EQU (CH.sub.3).sub.3 SO.sup..sym. CH.sub.3 SO.sub.4.sup.63 (II) and thereafter, without isolating said trimethyloxosulphonium methyl sulphate, contacting the same with a ketone of the formula ##STR2## in which X, Y and Z have the meanings indicated above, in the presence of a base and in the presence of an inert organic diluent, at a temperature between 0.degree. C. and 60.degree. C.