5-Pyrimidinecarboxamides and treatment of leukemia and tumors therewith
US4634707A · kind A · utility
14Cited by
5References
24Claims
0Family size
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Key dates
| Filing date | Feb 8, 1985 |
| Grant date | Jan 6, 1987 |
| Priority date | — |
| Expiry date | Feb 8, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/66
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel 5-pyrimidinecarboxamides useful for regressing or inhibiting the growth of leukemia and tumors in mammals. The compounds have the formula: ##STR1## wherein: R is hydrogen, 2- or 3-halo, 4-fluoro, 2-methyl, 2- or 4-alkoxy, or 2- or 4-trifluoromethyl, and R.sub.1 is hydrogen; or PA1 R is 2-fluoro and R.sub.1 is 4-fluoro; or PA1 R is 2-methoxy and R.sub.1 is 5-methyl; and PA1 R.sub.2 and R.sub.3 are hydrogen atoms or carbohydrate residues; and, with the exception of the compound wherein R is 4-methoxy and R.sub.1 is hydrogen, the pharmacologically acceptable acid-addition salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.