Antihypertensive esters of 1,4-dihydro-2,6-dimethyl-3-(alkoxycarbonyl or alkoxyalkoxycarbonyl)-4-(substituted phenyl)-pyridine-5-carboxylic acid
US4634712A · kind A · utility
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18Claims
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Key dates
| Filing date | May 14, 1985 |
| Grant date | Jan 6, 1987 |
| Priority date | — |
| Expiry date | May 14, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
##STR1## Esters I (Ar=3-nitrophenyl or 2,3-dichlorophenyl, A=C.sub.2 -C.sub.6 alkylene, R=C.sub.1 -C.sub.6 alkyl optionally C.sub.1 -C.sub.6 alkoxy monosubstituted, R.sub.1 =C.sub.1 -C.sub.4 alkyl) have antihypertensive activity and are effective against coronary heart diseases. They are prepared starting from the aldehyde ArCHO and esters of acetoacetic acid and 3-aminocrotonic acid. Pharmaceutical preparations containing them are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.