Vaccine, method for its preparation, and use thereof in vaccinating humans against rotavirus infection
US4636385A · kind A · utility
26Cited by
5References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 15, 1985 |
| Grant date | Jan 13, 1987 |
| Priority date | — |
| Expiry date | Feb 15, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S424/813
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A live rotavirus vaccine against bovine and human rotaviruses comprising a strain of live bovine rotavirus which does not hemagglutinate primate red blood cells, gives at least about 20 fold higher titers when neutralized with antiserum therefor as compared to heterologous bovine or primate rotaviruses, and has a migration pattern of its RNA genome segments when determined by PAGE substantially as shown by lane WC3 in FIG. 1, the strain of bovine rotavirus having been serially passaged in primate kidney tissue culture a sufficient number of times that when administered to humans the vaccine is immunogenic without causing disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.