Resolution of racemates of amino acids
US4636470A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 17, 1984 |
| Grant date | Jan 13, 1987 |
| Priority date | — |
| Expiry date | Aug 17, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P13/222
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Racemates of optically active amino acid substituted at the carbonyl position wherein the alpha amino acid nitrogen is underivatized and can be resolved using a two phase solvent system. The racemate is dissolved in a substantially water immiscible organic material which is a solvent for said amino acid racemate but not for the corresponding amino acids. The racemate is also dissolved in water (aqueous phase) and is in equilibrium with the racemate in the organic phase. One of the optical isomers of the amino acid racemate in the aqueous phase is enzymatically hydrolyzed to the corresponding amino acid and is recovered. The preferred product is L-phenylalanine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.